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Updated: Mar 20, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

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Nucleoside analogs: ready to enter the era of precision medicine?

Joseph Ciccolini1, Cindy Serdjebi2, Hau Le Thi Thu1

  • 1a SMARTc Unit , Inserm S_911 CRO2 Aix-Marseille University , Marseille , France.

Expert Opinion on Drug Metabolism & Toxicology
|May 25, 2016
PubMed
Abstract

Insights

Precision medicine can optimize cancer treatment using nucleoside analogs. Biomarkers and adaptive dosing strategies are key to improving the efficacy and safety of these vital chemotherapy drugs.

Area of Science:

  • Oncology
  • Pharmacology
  • Genetics

Background:

  • Precision medicine is crucial for optimizing cancer treatment.
  • While targeted therapies are common, traditional cytotoxic agents remain fundamental in oncology.
  • Nucleoside analogs are widely employed in treating various cancers, often in combination therapies.

Purpose of the Study:

  • To review current knowledge on biomarkers for nucleoside analog therapy.
  • To explore pharmacokinetic/pharmacodynamic relationships of nucleoside analogs.
  • To provide insights into implementing precision medicine strategies for nucleoside analogs in oncology.

Main Methods:

  • Review of existing literature on biomarkers and nucleoside analogs.
  • Analysis of pharmacokinetic and pharmacodynamic data.
  • Discussion of strategies for bedside implementation of bioguided therapy.

Main Results:

  • Several tumor and germline markers are associated with clinical outcomes for nucleoside analog therapy.
  • Bioguided strategies can significantly improve the efficacy-toxicity balance of these drugs.
  • Pharmacogenetic, tumor genomic, and adaptive dosing approaches are promising.

Conclusions:

  • Nucleoside analogs can be integrated into precision medicine approaches in oncology.
  • Biomarker-driven and adaptive dosing strategies are essential for optimizing their use.
  • Further research and clinical implementation are needed to fully realize their potential in personalized cancer care.
Keywords:
Nucleoside analoguesadaptive dosingpharmacogeneticspharmacokineticstherapeutic drug monitoring

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