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Updated: Mar 20, 2026

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
Published on: February 1, 2020
Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology
Laura M Desrochers1, Marc A Antonyak1, Richard A Cerione1
1Department of Molecular Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Abstract:
The generation and shedding of extracellular vesicles (EVs), including exosomes and microvesicles (MVs), by cells has emerged as a form of intercellular communication with important roles in several physiological processes and diseases such as cancer. These membrane-enclosed packets can transfer specific proteins, RNA transcripts, microRNAs, and even DNA to target cells, thereby altering their function. Despite the exponential growth of the EV field, a great deal remains unclear about the mechanisms that regulate exosome and MV biogenesis, as well as about how to isolate different classes of EVs and how to best take advantage of them for clinical applications.
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