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Related Concept Videos

Development of the Lymphatic System01:15

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
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Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Update on orbital lymphatic malformations.

Sara E Lally1

  • 1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Current Opinion in Ophthalmology
|May 25, 2016
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Summary
This summary is machine-generated.

Lymphatic malformations are challenging to treat, often recurring after therapy. Recent research focuses on identifying effective treatments, including sclerosing agents for macrocysts and potential antilymphangiogenic agents.

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Area of Science:

  • Vascular Anomalies
  • Pediatric Surgery
  • Dermatology

Background:

  • Lymphatic malformations are congenital vascular anomalies characterized by abnormal lymphatic vessel development.
  • These malformations present diagnostic and therapeutic challenges due to their infiltrative nature and tendency for recurrence.

Purpose of the Study:

  • To review the 2015 literature on lymphatic malformations.
  • To provide updated information on disease identification and management.
  • To highlight recent advances in therapeutic strategies.

Main Methods:

  • Literature review of published studies from 2015.
  • Analysis of therapeutic modalities for lymphatic malformations.
  • Evaluation of treatment outcomes and challenges.

Main Results:

  • Treatment of lymphatic malformations is complex, with frequent recurrences reported.
  • Ongoing studies aim to correlate specific lesion types with successful therapeutic modalities.
  • Current treatment options encompass both nonsurgical and surgical approaches.

Conclusions:

  • Lymphatic malformations pose significant treatment difficulties due to their disregard for tissue planes.
  • Sclerosing agents demonstrate promise for treating macrocystic lymphatic malformations.
  • Further research into disease development is necessary, with antilymphangiogenic agents offering potential for targeted therapy.