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Related Experiment Videos

Video fluorescein angiography: method and clinical application.

S Wolf1, F Jung, H Kiesewetter

  • 1Augenklinik der Rheinisch-Westfälischen Technischen Hochschule, Aachen, Federal Republic of Germany.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1989
PubMed
Summary

Video fluorescein angiography objectively measures retinal blood flow. This study established normal circulation parameters, including arm-retina time (ART), arteriovenous passage time (AVP), and mean arterial dye-bolus velocity (MDV), in healthy individuals.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Physiology

Background:

  • Evaluating retinal blood flow is crucial for diagnosing and monitoring various ocular conditions.
  • Traditional methods for assessing retinal circulation can be subjective and time-consuming.

Purpose of the Study:

  • To establish objective, clinically applicable methods for quantifying retinal blood-flow parameters using video fluorescein angiography.
  • To determine normal reference values for key retinal circulation parameters in a healthy population.

Main Methods:

  • Utilized video fluorescein angiography combined with a picture-analyzing system for objective optical density measurements.
  • Quantified retinal circulation parameters: arm-retina time (ART), arteriovenous passage time (AVP), and mean arterial dye-bolus velocity (MDV).

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  • Derived normal values from 75 healthy volunteers and assessed intraindividual variation in 10 volunteers.

    • Main Results:

    • Established mean normal values: ART (11.2 ± 3.3 s), AVP (1.45 ± 0.4 s), and MDV (6.39 ± 1.7 mm/s).
    • Found no significant correlation between pulse/blood pressure and the measured retinal circulation parameters.
    • Determined coefficients of variation for intraindividual reproducibility: ART (18%), AVP (10%), and MDV (26%).

    Conclusions:

    • Video fluorescein angiography with image analysis provides a reliable and objective method for assessing retinal blood flow.
    • The study provides normative data for ART, AVP, and MDV, essential for clinical interpretation.
    • These parameters show acceptable intraindividual variability, supporting their use in clinical practice.