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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
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Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

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Cumulative Risk of Metabolic Syndrome Correlated with the Coexistence of (-1306C/T) and Altered Circulating MMP2

S S Yadav1, R K Mandal2, M K Singh3

  • 1Department of Pharmacology and Therapeutics, King George's Medical University, Lucknow.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|May 25, 2016
PubMed
Abstract

Insights

Genetic variations in Matrix Metalloproteinase-2 (MMP-2) are linked to metabolic syndrome (MetS) risk. Elevated serum MMP-2 levels were observed in MetS patients, suggesting a potential biomarker for disease susceptibility.

Area of Science:

  • Genetics
  • Biochemistry
  • Metabolic Diseases

Background:

  • Metabolic syndrome (MetS) pathogenesis involves genetic and environmental factors.
  • Matrix Metalloproteinases (MMPs) are implicated in various physiological processes.
  • Investigating MMP gene variants' role in MetS susceptibility is crucial.

Purpose of the Study:

  • To analyze the association of Matrix Metalloproteinase (MMP) gene variants, specifically MMP-1 (-1607 1G/2G) and MMP-2 (-1306 C/T), with MetS susceptibility.
  • To evaluate the effect of these gene variants on serum MMP levels.
  • To determine potential clinical implications for MetS risk identification.

Main Methods:

  • Study included 370 subjects with a 1:1 case-control distribution.
  • MetS diagnosis based on modified NCEP-ATP III criteria.
  • Genotyping performed using PCR-RFLP; serum MMP levels measured by ELISA.

Main Results:

  • Serum MMP-2 levels were significantly higher in MetS cases (p<0.001).
  • The MMP-2 (-1306 C/T) variant, particularly the TT genotype, was significantly associated with increased MetS risk (p=0.032; OR=2.31).
  • No significant association was found between MMP-1 (-1607 1G/2G) and MetS risk.

Conclusions:

  • The MMP-2 (-1306 C/T) gene variant may be associated with an increased risk of developing MetS.
  • Elevated serum MMP-2 levels in MetS patients correlate with clinical parameters.
  • This research may aid in identifying individuals at high risk for MetS and its complications.

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