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Related Concept Videos

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Related Experiment Video

Updated: Mar 20, 2026

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
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The chorionic bump: Etiologic insights from two pathologic pregnancies.

Joseph R Wax1, Hagen Blaszyk2, Michael Jones2

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine.

Journal of Clinical Ultrasound : JCU
|May 25, 2016
PubMed
Summary
This summary is machine-generated.

Chorionic bumps, a rare finding in pregnancy, may be linked to placental issues like complete mole or trisomy 18. Further research is needed to understand their cause and clinical significance.

Keywords:
aneuploidychorionic bumpgestational trophoblastic diseaseultrasound

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Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Diagnostic Ultrasound

Background:

  • The clinical significance and etiology of chorionic bumps are not well understood.
  • Chorionic bumps are uncommon sonographic findings during pregnancy.

Observation:

  • Two cases of pregnancies with chorionic bumps are presented.
  • One case was diagnosed with a complete hydatidiform mole.
  • The other case involved trisomy 18.

Findings:

  • The study hypothesizes that placental pathology, such as edema and hydropic villi, may cause chorionic bumps.
  • This suggests a potential link between placental abnormalities and the sonographic appearance of chorionic bumps.

Implications:

  • Chorionic bumps may indicate underlying placental pathology or chromosomal abnormalities.
  • Further studies are required to establish an association between chorionic bumps and aneuploidy.
  • This finding may influence the diagnostic approach and management of pregnancies with chorionic bumps.