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Methotrexate-induced erythema multiforme.

S W Taylor1, D R Barnhill, T W Burke

  • 1Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200.

Gynecologic Oncology
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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Methotrexate, a folic acid antagonist, can cause rare skin reactions like erythema multiforme in cancer treatment. Discontinuing methotrexate therapy typically resolves these cutaneous reactions.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Methotrexate is a folic acid antagonist used in treating neoplastic diseases.
  • While effective, methotrexate can cause toxic effects, though cutaneous reactions are uncommon.

Observation:

  • A patient receiving low-dose methotrexate for gestational trophoblastic neoplasia developed erythema multiforme.
  • Erythema multiforme presented as pruritic papular dermatitis on the extremities, requiring biopsies for diagnosis.

Findings:

  • The patient's condition resolved spontaneously upon discontinuation of methotrexate therapy.
  • This case highlights a rare cutaneous adverse effect of methotrexate.

Implications:

  • Clinicians should consider erythema multiforme in patients on methotrexate presenting with characteristic skin lesions.

Related Experiment Videos

  • Switching to an alternative regimen is recommended for patients experiencing methotrexate-induced erythema multiforme.