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Updated: Mar 20, 2026
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
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Selected benign cutaneous lesions that may simulate melanoma histologically
1Division of Surgical Pathology and Cytopathology, University of Virginia Medical Center, Room 3020, 1215 Lee St, Charlottesville, Virginia 22908-0214.
Seminars in Diagnostic Pathology
|May 26, 2016
Summary
Differentiating cutaneous melanomas from other skin lesions is crucial due to their varied presentations. This review covers key entities that mimic melanoma, aiding accurate diagnosis.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Cutaneous melanomas exhibit diverse clinical and pathological features.
- Accurate diagnosis is essential for appropriate patient management.
Purpose of the Study:
- To review and discuss various benign and atypical lesions that can be mistaken for cutaneous melanoma.
- To aid clinicians and pathologists in the differential diagnosis of melanoma.
Main Methods:
- Review of relevant literature and case studies.
- Analysis of characteristic features of differential diagnostic entities.
Main Results:
- Identified entities include melanocytic hyperplasia, cellular nodules in congenital nevi, atypical lentiginous melanocytic proliferations, special site nevi, epithelioid histiocytoma, neurothekeoma, cellular schwannoma, and proliferating scars.
- These lesions share some overlapping features with melanoma, necessitating careful evaluation.
Conclusions:
- Distinguishing melanoma from mimics requires a thorough understanding of histopathological criteria.
- Awareness of these entities improves diagnostic accuracy and patient outcomes.
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