Related Experiment Video
Updated: Mar 20, 2026
Knee Arthrocentesis in Adults
Published on: February 25, 2022
A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery
Georgios I Drosos1, Athanasios Ververidis1, Christos Valkanis1
1Department of Orthopaedic Surgery, Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Dragana, 68100 Alexandroupolis, Greece.
Background:
The aim of this study was to compare the topical to IV tranexamic acid (TXA) administration of the same dose, given at the same time in patients who underwent TKR using an enhanced recovery after surgery (ERAS) regime.
Methods:
Ninety patients were randomized in control group, and IV and topical application groups received 1 g TXA.
Results:
Blood loss and transfusion requirements in control group were statistically higher compared to both TXA groups (p < 0.05). Length of stay was the same in all groups.
Conclusions:
TXA reduced significantly the blood loss and the need for transfusion in ERAS primary unilateral TKR.
