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Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies
Iranian Journal of Pediatric Hematology and Oncology
|May 26, 2016
Summary
This meta-analysis found no significant association between the RFC1 G80A polymorphism and acute lymphoblastic leukemia (ALL) risk overall or by ethnicity. Further research should explore gene-gene and gene-environment interactions for ALL risk.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The RFC1 G80A polymorphism is implicated as a cancer risk factor.
- Previous studies on its association with acute lymphoblastic leukemia (ALL) risk yielded controversial results.
Purpose of the Study:
- To conduct a meta-analysis to precisely estimate the relationship between the RFC1 G80A polymorphism and ALL risk.
Main Methods:
- A comprehensive literature search was performed across major databases (PubMed, Embase, Web of Science, Cochrane, Google Scholar) up to February 2016.
- Ten studies involving 2,168 ALL cases and 2,693 controls were included.
- Subgroup analyses based on ethnicity were conducted using CMA 2.0 software.
Main Results:
- No significant association was found for allelic, dominant, recessive, or homozygote models.
- A significant association was observed under the heterozygote model (OR = 1.368, P=0.018).
- Stratified analyses by ethnicity showed no significant association in Asian or Caucasian populations.
Conclusions:
- The RFC1 G80A polymorphism is not associated with an increased risk of ALL.
- Future research should investigate gene-gene and gene-environment interactions in relation to ALL risk.
