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Updated: Mar 20, 2026

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
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Activators and repressors: A balancing act for X-inactivation

Leeanne Goodrich1, Barbara Panning1, Karen Nicole Leung1

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, United States.

Seminars in Cell & Developmental Biology
|May 26, 2016
PubMed
Summary

Understanding X-chromosome inactivation requires studying the transcriptional regulators of Xist. This review explores how Xist is upregulated in female cells, comparing ex vivo and in vivo studies.

Keywords:
Early post-implantation developmentEmbryonic stem cellEpiblast stem cellNon-coding RNAPluripotencyRandom X-chromosome inactivationRlim/Rnf12TsixX-inactivation centerXist

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