Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Concepts of Health and Illness01:29

Concepts of Health and Illness

19.3K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
19.3K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

821
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
821
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

344
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
344
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

311
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
311
Ethical Issues01:27

Ethical Issues

2.5K
Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
2.5K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

1.2K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta-Analyses.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Statin use does not impair muscle health in older adults: findings from the SCOPE study.

Aging clinical and experimental research·2026
Same author

Global education and training in geriatrics: mapping transnational initiatives and their complementarities.

European geriatric medicine·2026
Same author

Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations.

Journal of cachexia, sarcopenia and muscle·2025
Same author

Chronic stress and functional health in older adults with concerns about falling: a study protocol of a randomized controlled trial with multicomponent exercise intervention (FEARFALL).

Trials·2024
Same author

Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study.

Aging clinical and experimental research·2023

Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K

Frailty - From concept to clinical practice.

Cornel C Sieber1

  • 1Institute for Biomedicine of Ageing, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany; Department of General Internal Medicine and Geriatrics, Hospital St. John of Lord, Regensburg, Germany.

Experimental Gerontology
|May 26, 2016
PubMed
Summary

Frailty, a geriatric syndrome, shares links with sarcopenia, the age-related loss of muscle mass. Understanding cellular senescence offers new ways to delay aging and improve healthspan through lifestyle interventions.

Keywords:
DefinitionDiagnosisFrailtyFunctionalityPathophysiologySarcopeniaTreatment

More Related Videos

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

799
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K

Related Experiment Videos

Last Updated: Mar 20, 2026

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

1.5K
Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

799
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

17.2K

Area of Science:

  • Gerontology and geriatric medicine
  • Cellular biology and aging research

Background:

  • Frailty is a significant geriatric syndrome impacting older adults' functionality and independence.
  • Physical frailty shows considerable overlap with sarcopenia, the age-related decline in muscle mass.
  • Aging was traditionally viewed as immutable, but cellular senescence research challenges this perspective.

Purpose of the Study:

  • To explore the growing interest in frailty and sarcopenia among scientists and clinicians.
  • To highlight the increasing consensus on defining these syndromes.
  • To discuss the potential of interventions in modifying the aging process and compressing morbidity.

Main Methods:

  • Review of current understanding of frailty and sarcopenia.
  • Examination of the role of cellular senescence in aging.
  • Analysis of lifestyle interventions (diet, physical activity) and pharmacological approaches.

Main Results:

  • Growing consensus on definitions of frailty and sarcopenia facilitates common understanding.
  • Cellular senescence research provides new insights into potentially delaying age-related conditions.
  • Lifestyle choices and pharmacological interventions show promise in optimizing aging and extending healthspan.

Conclusions:

  • Frailty and sarcopenia are key geriatric syndromes with significant implications for quality of life.
  • Interventions targeting the biology of aging, including lifestyle modifications, can potentially compress late-life morbidity.
  • Further research into cellular senescence and effective interventions is crucial for public health benefits.