Dose-modification factor for accumulated dose to cell nucleus due to protein-bound 3H

The purpose of this work was to estimate the dose-modification factor for accumulated dose in the cell nucleus due to protein-bound 3H in animal organs. The animal tissues were modeled to make a simplified theoretical estimation of the extent of dose modification due to the differential distribution of proteins between the cell nucleus and the extranuclear region. The results of theoretical calculation were applied to the case of mouse organs for which various cytological factors were determined experimentally. It was found that the dose-modifying factor (f) for mouse organs was between about 0.8 and 1.5, indicating that dose modification due to protein localization is of minor importance for the dosimetry of internally retained 3H.