Asymmetric axonal edge guidance: a new paradigm for building oriented neuronal networks
Renaud Renault1, Jean-Baptiste Durand, Jean-Louis Viovy
1UMR 168 Physico-Chimie Curie, CNRS, PSL Research University, Institut Curie, 75005, Paris, France. catherine.villard@curie.fr.
Lab on a Chip
|May 27, 2016
Abstract:
We present a novel kind of directional axon guides for brain-on-a-chip applications. Contrarily to previous works, the directionality in our design is created by rerouting axons growing in the unwanted direction back to their original compartment while leaving the other growth direction unaffected. This design yields state-of-the-art levels of directionality without the disadvantages of previously reported technologies.
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