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Postneurosurgical Central Nervous System Infection Due to Enterococcus faecalis Successfully Treated With

Trisha Patel1, Mark E Lewis1, Michelle L Niesley1

  • 1Pharmacy, †Clinical Research, and ‡Infectious Disease, Cancer Treatment Centers of America at Eastern Regional Medical Center, Philadelphia, PA.

Infectious Diseases in Clinical Practice (Baltimore, Md.)
|May 27, 2016
PubMed

Insights

Post-neurosurgical infections by Enterococcus faecalis are rare. This case highlights successful treatment of refractory Enterococcus faecalis ventriculitis, meningitis, and cerebritis using intraventricular vancomycin in an oncology patient.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Oncology

Background:

  • Post-neurosurgical infections involving Enterococcus species are uncommon.
  • Standard intravenous antibiotic therapy may fail in refractory cases.
  • Intraventricular antibiotics are a recommended alternative when intravenous treatment is insufficient.

Purpose of the Study:

  • To report a case of refractory Enterococcus faecalis infection post-neurosurgery.
  • To demonstrate the efficacy of intraventricular vancomycin in such cases.

Main Methods:

  • A case study of an oncology patient with post-neurosurgical ventriculitis, meningitis, and cerebritis.
  • Treatment involved the administration of intraventricular vancomycin.
  • Infection was caused by a refractory strain of Enterococcus faecalis.

Main Results:

  • Successful resolution of ventriculitis, meningitis, and cerebritis.
  • The patient's refractory Enterococcus faecalis infection was effectively managed.
  • Intraventricular vancomycin proved to be a successful therapeutic strategy.

Conclusions:

  • Intraventricular vancomycin can be an effective treatment for refractory Enterococcus faecalis central nervous system infections post-neurosurgery.
  • This approach offers a viable option when conventional therapies fail.
  • Highlights the importance of considering targeted intraventricular antibiotic administration.
Keywords:
infectionintraventricularoncologyvancomycin

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