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Mutagenesis and Functional Analysis of Ion Channels Heterologously Expressed in Mammalian Cells
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Published on: October 1, 2010

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Poring over two-pore channel pore mutants

Christopher J Penny1, Sandip Patel1

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT.

Messenger (Los Angeles, Calif. : Print)
|May 27, 2016
PubMed
Summary

Two-pore channels (TPCs) are key voltage-gated ion channels in the endolysosomal system. Mutagenesis studies linked to homology models reveal crucial insights into TPC function and molecular physiology.

Keywords:
NAADPTPC1TPC2homology modellingsite-directed mutagenesisstructure-functionvoltage-gated ion channel

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