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Published on: November 1, 2018

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Protracted Clinical Course of Postinfectious Glomerulonephritis in a Previously Healthy Child

Camilla Grøndahl1, Søren Rittig1, Johan Vestergaard Povlsen2

  • 1Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark.

Case Reports in Nephrology and Dialysis
|May 27, 2016
PubMed

Insights

Acute postinfectious glomerulonephritis (PIGN) in children usually resolves quickly. This case highlights a rare protracted PIGN with persistent symptoms, requiring a renal biopsy for diagnosis.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Pathology

Background:

  • Acute postinfectious glomerulonephritis (PIGN) commonly follows streptococcal infections in children.
  • PIGN typically presents as a self-limiting condition with a favorable prognosis.

Observation:

  • A previously healthy 4-year-old boy presented with prolonged PIGN symptoms.
  • The patient experienced recurrent gross hematuria, proteinuria, and low C3c complement levels with normal creatinine.

Findings:

  • Renal biopsy after 6 months revealed pathology consistent with acute endocapillary glomerulonephritis.
  • The protracted course and nephrotic-range proteinuria prompted the biopsy.

Implications:

  • This case underscores the possibility of atypical PIGN presentations in children.
  • Understanding protracted PIGN is crucial for accurate diagnosis and management.
  • Highlights the importance of renal biopsy in complex pediatric glomerulonephritis cases.

Keywords:
Acute postinfectious glomerulonephritisComplement C3HaematuriaProteinuria

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