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Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
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High prevalence of side population in human cancer cell lines
Maximilian Boesch1,2, Alain G Zeimet3, Heidi Fiegl3
1Institute of Immunobiology, Kantonsspital St. Gallen, 9007 St. Gallen, Switzerland.
Oncoscience
|May 27, 2016
Abstract:
Cancer cell lines are essential platforms for performing cancer research on human cells. We here demonstrate that, across tumor entities, human cancer cell lines harbor minority populations of putative stem-like cells, molecularly defined by dye extrusion resulting in the side population phenotype. These findings establish a heterogeneous nature of human cancer cell lines and argue for their stem cell origin. This should be considered when interpreting research involving these model systems.
