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Updated: Mar 20, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

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Mycobacterium chelonae Scleral Abscess After Intravitreal Ranibizumab Injection.

Ilya M Sluch¹, Rhea L Siatkowski, Vinay A Shah

¹Dean McGee Eye Institute, Oklahoma City, OK.

|May 27, 2016

Summary

This summary is machine-generated.

A rare scleral abscess caused by Mycobacterium chelonae occurred after an intravitreal ranibizumab injection for diabetic macular edema. Prompt treatment with drainage and antibiotics led to complete resolution and vision recovery.

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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

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Published on: December 7, 2016

Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Background:

Intravitreal injections of vascular endothelial growth factor inhibitors, such as ranibizumab, are standard treatments for neovascular age-related macular degeneration and diabetic macular edema.
While generally safe, intravitreal injections carry a small risk of complications, including endophthalmitis and localized infections.

Observation:

A 54-year-old female developed a scleral abscess at the injection site two weeks after receiving an intravitreal ranibizumab injection for diabetic macular edema.
The abscess was caused by Mycobacterium chelonae, a rapidly growing non-tuberculous mycobacterium.

Findings:

The patient was treated with incision and drainage of the abscess, along with a combination of subconjunctival, topical, and oral antibiotics (amikacin and clarithromycin).
Following four weeks of treatment, the scleral abscess and associated inflammation completely resolved.
The patient's best-corrected visual acuity returned to the pre-injection level.

Implications:

Scleral abscesses are extremely rare but serious complications following intravitreal injections.
Early diagnosis, surgical drainage, and appropriate combination antibiotic therapy are crucial for successful management.
This case highlights the importance of considering atypical organisms in post-injection infections and the efficacy of targeted antimicrobial treatment.