Related Experiment Video
Updated: Mar 20, 2026
06:36
A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
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The Role of the Mucosa in Normal and Abnormal Bladder Function
Christopher H Fry1, Bahareh Vahabi2
1School of Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol, UK. chris.fry@bristol.ac.uk.
Basic & Clinical Pharmacology & Toxicology
|May 27, 2016
Summary
The urinary bladder's mucosa acts as a dynamic sensory structure, monitoring bladder fullness and urine composition. This sensory system offers potential drug targets for conditions like overactive bladder.
Area of Science:
- Urology
- Neuroscience
- Cell Biology
Background:
- The urinary bladder mucosa separates urine from the detrusor muscle.
- Beyond a barrier, it provides sensory functions, detecting bladder filling and urine composition.
Purpose of the Study:
- To explore the sensory role of the bladder mucosa.
- To identify potential drug targets for bladder pathologies.
Main Methods:
- The study reviews the functional anatomy of the bladder mucosa.
- It discusses the release of chemical mediators and their effects on afferent nerves and muscle components.
Main Results:
- The bladder mucosa is a functional sensory structure involving epithelial and lamina propria layers.
- Chemical mediators like ATP and nitric oxide modulate nerve and muscle activity.
- This system's gain is heightened in overactive bladder and bladder pain syndrome.
Conclusions:
- The bladder mucosa is a dynamic sensory system with potential therapeutic targets.
- Further research is needed to understand mediator release regulation, interstitial cell roles, and urothelium-muscle communication.
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