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Acute Angioedema Triggered by Daptomycin

Valentin Gisler1, Sabine Müller2, Lionel Müller3

  • 1Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.

Infectious Diseases and Therapy
|May 28, 2016
PubMed
Abstract

Insights

Daptomycin, an antibiotic for Staphylococcus aureus infections, can rarely cause acute angioedema, a serious allergic reaction. This case highlights the potential for immediate-type hypersensitivity to daptomycin, even on initial exposure.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Allergy and Immunology

Background:

  • Daptomycin is a cyclic lipopeptide antibiotic commonly used for Staphylococcus aureus bloodstream infections.
  • While generally safe, serious adverse events are rare.
  • This report details a case of acute angioedema potentially triggered by daptomycin.

Purpose of the Study:

  • To report a rare case of acute angioedema induced by daptomycin.
  • To raise awareness among clinicians about immediate-type hypersensitivity reactions to daptomycin.

Main Methods:

  • A 60-year-old female patient with persistent S. aureus bacteremia and acute kidney injury was treated with daptomycin and ceftriaxone.
  • The patient developed acute angioedema (lip and tongue swelling, dyspnea) shortly after the first daptomycin dose.
  • An intradermal skin test confirmed hypersensitivity to daptomycin.

Main Results:

  • The patient experienced acute angioedema following daptomycin administration.
  • Switching to vancomycin led to a favorable clinical outcome.
  • Intradermal testing showed a positive reaction to daptomycin and a negative reaction to ceftriaxone.

Conclusions:

  • Daptomycin was identified as the probable or certain cause of acute angioedema in this patient.
  • Clinicians should consider daptomycin as a potential cause of immediate-type hypersensitivity reactions, including angioedema, even with initial use.
Keywords:
AnaphylaxisAngioedemaDaptomycin

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