Comparison of qualitative and semiquantitative strain elastography in breast lesions for diagnostic accuracy

Strain elastography can be purely qualitative or semiquantitative using both strain score and strain ratio. The aim of this study was to establish the accuracy of semiquantitative elastography using both strain score and strain ratio in differentiating benign from malignant breast masses. The diagnostic performance of the two methods was analysed for any statistically significant difference.

A prospective study was carried out from May to December 2014 in the University of Nairobi, Department of Diagnostic Imaging and Radiation Medicine. One hundred and eighteen patients referred for breast ultrasound following clinical detection of masses certified the inclusion criteria. All solid masses identified on grey scale imaging were subjected to strain elastography. Elastographic findings were represented in both strain score and strain ratio. Comparison of diagnostic performance with histological findings as the gold standard for all detected solid masses was done. Fisher's exact test and receiver operating characteristics curves were applied for statistical analysis to look for any significant differences between the diagnostic performance of strain score and strain ratio.

Out of the 118, three patients did not attend for all the examinations and three biopsy results were misplaced therefore analysis was done for 112 subjects. The sensitivity, specificity, positive predictive value and negative predictive value of elasticity strain (Ueno) score were 0.86, 0.96, 0.89 and 0.96 respectively. For the strain ratio the values were 0.93, 0.96, 0.90 and 0.96 respectively. Fisher's exact test P values comparing the sensitivity and specificity were 0.69 and 1.00 respectively not considered significant at p 0.05 levels. The areas under the curve (AUCs) from the receiver operating characteristic (ROC) curves were 0.972 and 0.976 for strain score and ratio respectively with a strong Pearson's correlation coefficient, r 0.79 indicating a high diagnostic accuracy for both methods but no statistically significant difference in performance.

Semiquantitative ultrasound elastography has good diagnostic accuracy in differentiating benign and malignant breast solid lesions and there is no statistically significant difference between strain score and strain ratio in sensitivity, specificity and accuracy.