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Related Concept Videos

Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem cell heterogeneity revealed.

Marianne S Andersen1, Kim B Jensen1

  • 1BRIC-Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark.

Nature Cell Biology
|May 28, 2016
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Summary
This summary is machine-generated.

Skin stem cells are crucial for maintaining the skin barrier. This study proposes a new model detailing how diverse cell types in the epidermis work together to sustain this vital protective layer.

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Area of Science:

  • Dermatology
  • Cell Biology
  • Tissue Engineering

Background:

  • The skin's primary function is a protective barrier against environmental factors.
  • The precise contribution of stem cells to epidermal barrier maintenance is debated.
  • The interfollicular epidermis is key to skin barrier integrity.

Purpose of the Study:

  • To investigate the role of stem cells in sustaining the skin's protective barrier.
  • To propose a novel model for epidermal maintenance involving diverse cell populations.
  • To clarify the cellular dynamics underlying skin barrier function.

Main Methods:

  • Detailed analysis of the interfollicular epidermis.
  • Cellular property assessment.
  • Development of a composite cell model for epidermal maintenance.

Main Results:

  • Identified specific cellular properties contributing to barrier function.
  • Proposed a model where heterogeneous cells collaborate for epidermal maintenance.
  • Highlighted the complex interplay of cells in sustaining the skin barrier.

Conclusions:

  • Stem cell contribution to skin barrier maintenance is multifaceted.
  • A composite model of epidermal cells explains barrier sustainment.
  • Further research into cellular heterogeneity can advance dermatology.