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Updated: Mar 20, 2026
Blood Flow Imaging with Ultrafast Doppler
Published on: October 14, 2020
Real-time simultaneous single snapshot of optical properties and blood flow using coherent spatial frequency domain
Michael Ghijsen1, Bernard Choi2, Anthony J Durkin3
1Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612, USA; Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.
Abstract:
In this work we present and validate a wide-field method for the real-time mapping of tissue absorption, scattering and blood flow properties over wide regions of tissue (15 cm x 15 cm) with high temporal resolution (50 frames per second). We achieve this by applying Fourier Domain demodulation techniques to coherent spatial frequency domain imaging to extract optical properties and speckle flow index from a single snapshot. Applying this technique to forearm reactive hyperemia protocols demonstrates the ability to resolve intrinsic physiological signals such as the heart beat waveform and the buildup of deoxyhemoglobin associated with oxygen consumption.
