Related Experiment Video
Updated: Mar 20, 2026

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
Published on: August 19, 2025
On Using Residual Voltage to Estimate Electrode Model Parameters for Damage Detection
Ashwati Krishnan1, Shawn K Kelly2
1Ashwati Krishnan is with the Department of Electrical and Computer Engineering and the Institute of Complex Engineered Systems (ICES), Carnegie Mellon University, Pittsburgh, PA 15213, USA. ashwatik@andrew.cmu.edu.
Abstract:
Current technology has enabled a significant increase in the number of electrodes for electrical stimulation. For large arrays of electrodes, it becomes increasingly difficult to monitor and detect failures at the stimulation site. In this paper, we propose the idea that the residual voltage from a biphasic electrical stimulation pulse can serve to recognize damage at the electrode-tissue interface. We use a simple switch circuit approach to estimate the relaxation time constant of the electrode model, which essentially models the residual voltage in biphasic electrical stimulation, and compare it with standard electrode characterization techniques. Out of 15 electrodes in a polyimide-based SIROF array, our approach highlights 3 damaged electrodes, consistent with measurements made using cyclic voltammetry and electrode impedance spectroscopy.
Related Concept Videos
The Electrical Double Layer
Potentiometer
Suppose the emf of a battery needs to be measured. If the battery is directly connected to a standard voltmeter, the measured quantity is...
Processes at Electrodes

