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Structural Characterization of Lecithin-Stabilized Tetracosane Lipid Nanoparticles. Part II: Suspensions.

M Schmiele¹, S Busch², H Morhenn³

¹Professur für Nanomaterialcharakterisierung (Streumethoden), Friedrich-Alexander-Universität Erlangen-Nürnberg , Staudtstr. 3, 91058 Erlangen, Germany.

The Journal of Physical Chemistry. B

|May 28, 2016

Summary

This study reveals that tetracosane nanocrystals, stabilized by 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), exhibit an unusual orthorhombic crystal structure. The DMPC stabilizer layer forms a thinner monolayer on these nanocrystals compared to emulsions.

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Area of Science:

Materials Science
Physical Chemistry
Nanotechnology

Background:

Colloidal suspensions are crucial in various applications.
Understanding the structure of nanocrystals and their stabilizers is key to controlling material properties.
1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a common phospholipid used as a stabilizer.

Purpose of the Study:

To investigate the molecular and microscopic structure of DMPC-stabilized tetracosane nanocrystals.
To determine the crystal structure of tetracosane and the organization of the DMPC stabilizer layer.
To explore the influence of temperature on the nanocrystal and stabilizer structure.

Main Methods:

Photon correlation spectroscopy
Transmission electron microscopy
Microcalorimetry
Wide-angle X-ray scattering (WAXS)
Small-angle X-ray and neutron scattering (SAXS, SANS)

Main Results:

Tetracosane nanocrystals display an unusual orthorhombic low-temperature crystal structure (space group Pca21).
This orthorhombic structure is typically observed in longer even-numbered n-alkanes.
The DMPC stabilizer forms a monolayer on the nanocrystals with a thickness of 10.5 Å, indicating a more tilted molecular orientation than in emulsions.

Conclusions:

The study elucidates the unique crystal structure of tetracosane nanocrystals.
The findings provide insights into the self-assembly and structural characteristics of phospholipid-stabilized nanomaterials.
The thinner DMPC layer suggests adaptation to the nanocrystal surface, impacting colloidal stability.