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Metabolic Crosstalk between Leishmania and the Macrophage Host
1Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, VIC 3010, Australia.
Trends in Parasitology
|May 29, 2016
Abstract:
Goldman-Pinkovich et al. have shown that intracellular stages of Leishmania actively sense arginine levels within the phagolysosome of the host macrophage and activate a MAP kinase-dependent response when arginine is reduced. This response may impact macrophages responses as well as being required for parasite intracellular replication.

