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Self, cortical midline structures and the resting state: Implications for Alzheimer's disease
Marina Weiler1, Georg Northoff2, Benito Pereira Damasceno3
1Neuroimaging Laboratory, Department of Neurology, University of Campinas (Unicamp), Brazil.
Alzheimer's disease (AD) impairs self-awareness by affecting episodic memory and brain regions like the Default Mode Network. These deficits impact the sense of self-continuity in AD patients.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Neurology
Background:
- Neurological and psychiatric diseases, including Alzheimer's disease (AD), can affect various aspects of the self.
- Self-unawareness, a key deficit in AD, is closely linked to episodic memory and the sense of continuity over time.
Purpose of the Study:
- To explore the origins of self-awareness deficits in Alzheimer's disease (AD) patients.
- To elucidate the role of neuroimaging in understanding these cognitive impairments.
Main Methods:
- Review of existing studies on self-awareness in neurological and psychiatric diseases.
- Analysis of neuroimaging research in Alzheimer's disease (AD) patients.
Main Results:
- Episodic and autobiographical memory impairments are evident in AD patients.
- Cortical midline structures, the Default Mode Network, and resting-state brain activity are crucial for processing self-related information.
Conclusions:
- Self-awareness deficits in AD are associated with impairments in episodic memory.
- Specific brain networks, including the Default Mode Network and cortical midline structures, are implicated in the loss of self-awareness in AD.
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