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Assessment of arterial stiffness in patients with venous thromboembolism: Separate or continuous circuits?

Ahmet Çağrı Aykan1, Engin Hatem1, Ezgi Kalaycıoğlu1

  • 11 Department of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon, Turkey.

Phlebology
|May 29, 2016
PubMed

Insights

Arterial stiffness, measured by cardio-ankle vascular index, is significantly higher in patients with venous thromboembolism. This finding suggests a link between arterial and venous circulation health.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology

Background:

  • Arterial stiffness is an indicator of cardiovascular health.
  • Venous thromboembolism (VTE) is a significant clinical condition.
  • The relationship between arterial stiffness and VTE requires further investigation.

Purpose of the Study:

  • To evaluate the association between arterial stiffness, assessed by the cardio-ankle vascular index (CAVI), and lower extremity venous thromboembolism (VTE).

Main Methods:

  • A cross-sectional observational study included 52 patients with recent VTE and 52 healthy controls.
  • Arterial stiffness was measured using the cardio-ankle vascular index (CAVI).
  • Multivariate logistic regression and ROC curve analysis were employed to assess the predictive value of CAVI for VTE.

Main Results:

  • Patients with VTE exhibited significantly higher CAVI (8.58 ± 1.60 vs. 7.05 ± 1.44, p < 0.001) and systolic blood pressure compared to controls.
  • CAVI was an independent predictor of VTE (OR = 1.864, 95% CI = 1.370-2.536).
  • A CAVI value > 7.8 demonstrated 82.7% sensitivity and 80.8% specificity for predicting VTE (AUC = 0.789).

Conclusions:

  • Arterial stiffness is increased in patients with venous thromboembolism.
  • This suggests a continuum between arterial and venous circulation, where insults may impact both systems.
  • CAVI may serve as a valuable biomarker for predicting VTE risk.

Keywords:
Arterial stiffnesscardio-ankle vascular indexdeep vein thrombosisvenous thromboembolism

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