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Maternal Serum Analytes as Predictors of Fetal Growth Restriction with Different Degrees of Placental Vascular

Matthew J Blitz1, Burton Rochelson1, Nidhi Vohra1

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Hofstra North Shore-LIJ School of Medicine, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA.

Clinics in Laboratory Medicine
|May 29, 2016
PubMed

Abnormal levels of maternal serum analytes have been associated with fetal growth restriction (FGR) and preeclampsia secondary to placental vascular dysfunction. Accurately identifying the FGR fetuses at highest risk for adverse outcomes remains challenging. Placental function can be assessed by Doppler analysis of the maternal and fetal circulation. Although the combination of multiple abnormal maternal serum analytes and abnormal Doppler findings is strongly associated with adverse outcomes, the predictive value remains too low to be used as a screening test in a low-risk population. Stratification of cases based on the severity of Doppler abnormalities may improve predictive models.

Keywords:
Absent or reverse end-diastolic velocityDoppler velocimetryFetal growth restrictionPlacental pathologyPlacental vascular dysfunctionSerum analytes

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