Related Experiment Video
Updated: Mar 20, 2026
10:13
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
14.3K
The Effect of Age on Post-EVAR Outcomes
Chien Yi M Png1, Rami O Tadros1, Peter L Faries1
1Department of Vascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY.
Annals of Vascular Surgery
|May 29, 2016
Summary
Older patients undergoing endovascular aneurysm repair (EVAR) face higher risks of complications and reinterventions due to complex anatomy. While EVAR is safe across age groups, younger patients experience better long-term survival.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Geriatric Medicine
Background:
- Endovascular Aneurysm Repair (EVAR) is a common treatment for abdominal aortic aneurysms.
- The impact of advanced age on EVAR outcomes requires further investigation.
Purpose of the Study:
- To investigate the relationship between increased age and post-EVAR outcomes.
- To compare EVAR results in patients younger than 70 years versus those 70 years and older.
Main Methods:
- A retrospective review of 1,380 patients who underwent EVAR.
- Analysis of computed tomography angiography data for 500 patients to assess anatomical variations.
- Comparison of outcomes between patients aged <70 and ≥70 years.
Main Results:
- Patients aged ≥70 had higher preoperative risk scores and more complex aneurysm anatomy (tortuosity, angulation, calcification).
- Older patients experienced higher rates of perioperative complications, endoleaks, and required more reinterventions.
- Despite similar AAA-related mortality, younger patients (<70 years) demonstrated improved overall survival and earlier discharge.
Conclusions:
- Advanced age is linked to more complex aneurysm morphology, leading to increased endoleaks and reinterventions post-EVAR.
- While EVAR is feasible in older adults, age-related anatomical factors contribute to poorer outcomes.
- Younger patients benefit from improved long-term survival following EVAR.
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
311
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
311
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
797
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
797
01:19The Effect of Aging on Tissues
4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
01:15Drug Dosing: Geriatric Patients
344
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
344
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
312
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
312
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
310
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
310