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Visuospatial problem solving, conceptual reasoning and sorting behaviour in multiple sclerosis out-patients.

A Jennekens-Schinkel1, E A van der Velde, E A Sanders

  • 1Neuropsychology Section, State University Leiden, The Netherlands.

Journal of the Neurological Sciences
|April 1, 1989
PubMed
Summary
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Most patients with Multiple Sclerosis (MS) in stable stages perform well on cognitive tests measuring visuospatial skills and reasoning. This indicates normal cognitive function in socially integrated MS patients not experiencing relapses.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Multiple Sclerosis (MS) can affect cognitive functions, including visuospatial problem-solving, conceptual reasoning, and set-shifting.
  • Understanding cognitive performance in MS patients during stable disease phases is crucial for assessing daily functioning.

Purpose of the Study:

  • To investigate visuospatial problem solving, conceptual reasoning, and set-shifting abilities in out-patients with definite and probable Multiple Sclerosis (MS).
  • To compare cognitive performance between MS patients and a healthy control group.

Main Methods:

  • Utilized standardized neuropsychological tests: Raven's Progressive Matrices, the Category Test, and the Wisconsin Modified Card Sorting Test.
  • Compared performance of MS patients (definite and probable) with a control group of healthy volunteers.

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  • Analyzed cognitive data considering disease stability and social integration.

    • Main Results:

    • No significant differences in cognitive performance were observed between the MS patient group and the healthy control group.
    • A small percentage of MS patients (18%) and controls (4%) showed slightly below-expected cognitive performance.
    • Illness variables did not significantly impact performance, and no distinction was found between definite and probable MS.

    Conclusions:

    • Most Multiple Sclerosis (MS) patients who are socially integrated and in stable disease stages exhibit normal visuospatial problem-solving, abstract reasoning, and set-shifting capabilities.
    • Cognitive function in these MS patients is comparable to healthy individuals, suggesting preserved higher-level cognitive abilities during remission periods.