Ultrastructural observation of liver tissue ablation induced by high-intensity focused ultrasound
S Q Cheng1, X D Zhou1, Z Y Tang1
1Shu-Qun Cheng, Xin-Da Zhou, Zhao-You Tang, Yao Yu, Liver Cancer Institute, Zhongshan Hospital, Shanghai Medical University, Shanghai 200032, China.
Aim:
To observe the ultrastructural changes of liver tissues on normal rabbit ablated by high-intensity focused ultrasound (HIFU).
Methods:
A single shot of 1.1 MHz focused ultrasound at an intensity of 500 W/cm(2) with 20-s duration of continuous exposure was applied intraoperatively in normal rabbit livers. Ultrastructural changes of the sonoablated lesion, as viewed by light and electron microscopy, were observed.
Results:
Liver cells at the center of the sonoablated lesion showed irreversible degeneration immediately after HIFU treatment; electron microscopy showed that although the liver cells appeared normal histologically, irregularly shaped cavities of about 0.3-0.5 μm in diameter were present in the cytoplasm.
Conclusion:
Thermal damages may be the main mechanism of HIFU-induced ablation of liver tissues besides cavitation effect.
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