Related Experiment Video For Colonoscopy
Updated: Mar 20, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Diagnostic value of occult fecal blood testing for colorectal cancer screening
1Kun Chen, Deng-Ao Jiao, Yang Zhang, Department of Epidemiology, Zhejiang Medical University, Hangzhou 310031, Zhejiang Province, China.
Aim:
To evaluate the diagnostic value of occult fecal blood testing in mass colorectal cancer screening.
Methods:
A reverse passive hemagglutination reaction fecal occult blood test (RPHA-FOBT) and colorectal cancer risk factor quantitative method were used as preliminary screening for colorectal cancer. A 60-cm fiber optic colonoscopy was used to validate the preliminary screen and was used to detect colorectal cancer in a community of 75813 subjects.
Results:
Compared to the 60-cm fiber optic colonoscopy as a standard reference, FOBT has a sensitivity of 41.9%, specificity of 95.8%, Youden's index of 0.38, and positive predictive value of 0.68%. These results increased with subject age from the first detection. A 3-year follow up in the target mass showed that all new cases had initially been FOBT-negative.
Conclusion:
The value of FOBT as an indicator of colorectal cancer in mass screening is limited.
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