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A microfluidic biosensor using graphene oxide and aptamer-functionalized quantum dots for peanut allergen detection.

Xuan Weng1, Suresh Neethirajan1

  • 1BioNano Laboratory, School of Engineering, University of Guelph, Guelph, Canada N1G 2W1.

Biosensors & Bioelectronics
|May 31, 2016
PubMed
Summary

A new quantum dot aptamer functionalized graphene oxide nano-biosensor offers rapid and sensitive food allergen detection. This microfluidic system provides a cost-effective alternative to traditional methods for on-site food safety analysis.

Keywords:
AptamerAra h 1Graphene oxideMicrofluidicsQuantum dots

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Rising food allergies and processed food consumption necessitate improved allergen detection methods.
  • Current methods like ELISA are time-consuming and costly.
  • Biosensors offer a rapid, sensitive, selective, and cost-effective alternative.

Purpose of the Study:

  • To develop a microfluidic system integrated with a quantum dots (Qdots) aptamer functionalized graphene oxide (GO) nano-biosensor.
  • To achieve simple, rapid, and sensitive detection of food allergens.
  • To provide a cost-effective and accurate on-site determination of food allergens.

Main Methods:

  • Utilized Qdots-aptamer-GO complexes as probes in a microfluidic system.
  • Exploited fluorescence quenching and recovery properties of GO for detection.
  • Developed a one-step 'turn on' homogenous assay on a microfluidic chip.

Main Results:

  • Achieved quantitative detection of Ara h 1 (peanut allergen) in approximately 10 minutes.
  • Demonstrated remarkable sensitivity and selectivity of the developed biosensor.
  • The system showed potential for extension to other food allergens.

Conclusions:

  • The integrated microfluidic biosensor is a promising tool for rapid, cost-effective, and accurate on-site food allergen determination.
  • This technology offers a significant advancement over conventional immunoassays.
  • The platform's adaptability allows for the detection of various food allergens by selecting appropriate aptamers.