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Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

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Web-based ecosystem software for virtual crossmatching in transplant programs.

Keylla S U Aita¹, Semiramis J H Monte², Adalberto S Silva³

¹Distance Education Centre, Federal University of Piaui, Rua Olavo Bilac - Bairro Centro, CEP: 64280001 Teresina, Piaui, Brazil.

Computers in Biology and Medicine

|May 31, 2016

Summary

This summary is machine-generated.

EpViX software aids organ transplantation by performing epitope reactivity analyses and virtual crossmatching. This tool facilitates donor-recipient compatibility assessments, improving transplant outcomes for high-immunologic risk patients.

Keywords:

Decision-making Epitope reactivity analyses HLA epitopes Virtual crossmatch Web-based software

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Area of Science:

Immunology
Bioinformatics
Medical Informatics

Background:

Donor-recipient compatibility is critical for transplant success and evaluating immunological risks.
Current data analysis tools struggle to simplify complex transplant data for practical decision-making.
High-immunologic risk recipients face challenges in finding suitable donors.

Purpose of the Study:

To describe the computational architecture of the EpViX ecosystem.
To introduce EpViX as a tool for epitope reactivity analyses and automated epitope virtual crossmatching.
To present EpViX as a facilitator for medical decision-making in organ transplantation.

Main Methods:

Developed EpViX as a freeware web-based application using the Ruby language.
EpViX integrates stakeholders in deceased donor transplant processes.
The software is accessible across various platforms including PCs, tablets, and smartphones.

Main Results:

Successfully developed a collaborative program for the organ donation process.
EpViX accurately predicts negative crossmatches, saving time and resources.
The software enables effective collaboration among stakeholders.

Conclusions:

EpViX is a significant advancement in organ transplantation, enhancing donor allocation for highly sensitized recipients.
The tool increases equity among recipients on waiting lists.
EpViX is a secure, intuitive, and user-friendly tool verified through data security and usability testing.