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Updated: Mar 20, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
[Construction of a physiological aging scale for healthy people based on a modified Delphi method]
Yao Long1, Xuan Zhou1, Pengfei Deng1
1Department of Epidemiology, School of Public Health, Nanchang University, Nanchang 330006, China.
Objective:
To build a physiological aging scale for healthy people.
Methods:
We collected age-related physiologic items through literature screening and expert interview. Two rounds of Delphi were implemented. The importance, feasibility and the degree of authority for the physiological index system were graded. Using analytic hierarchy process, we determined the weight of dimensions and items.
Results:
Using Delphy mothod, 17 physiological and other professional experts offered the results as follow: coefficient of expert authorities Cr was 0.86±0.03, coordination coefficients for the first and second round were 0.264(χ2=229.691, P<0.001) and 0.293(χ2=228.474,P<0.001), respectively. The consistency was good. The aging scale for healthy people included 3 dimensions, namely physical form, feeling movement and functional status. Each dimension had 8 items. The weight coefficients for the 3 dimensions were 0.54, 0.16, and 0.30, respectively. The Cronbach's α coefficient of the scale was 0.893, the reliability was 0.796, and the variance of the common factor was 58.17%.
Conclusion:
The improved Delphi method or physiological aging scale is satisfied, which can provide reference for the evaluation of aging.
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