Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Additional Subnuclear Structures

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...

Additional Subnuclear Structures

Additional Subnuclear Structures

The Nucleus

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

The Nucleus

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

The Nucleus

The Nucleus

Nuclear Protein Sorting

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Systematic deletion of symmetrical <i>CFTR</i> exons reveals new therapeutic targets for exon skipping antisense oligonucleotides.

NAR molecular medicine·2024

Same author

Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus.

Histochemistry and cell biology·2024

Same author

Keeping membraneless organelles apart.

Nature cell biology·2023

Same author

How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork.

Trends in biochemical sciences·2021

Same author

The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies.

Cells·2019

Same author

A role of the 53BP1 protein in genome protection: structural and functional characteristics of 53BP1-dependent DNA repair.

Aging·2019

Search research articles

Related Experiment Video

Updated: Mar 20, 2026

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Published on: June 28, 2024

Nuclear bodies: Built to boost.

Iain A Sawyer¹, Miroslav Dundr²

¹Department of Cell Biology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, North Chicago, IL 60064 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

The Journal of Cell Biology

|June 1, 2016

Summary

This summary is machine-generated.

The histone locus body concentrates factors essential for processing histone pre-mRNAs, providing the first direct evidence for this nuclear body function. This concentration accelerates crucial cellular reactions.

More Related Videos

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Published on: July 15, 2020

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

Related Experiment Videos

Last Updated: Mar 20, 2026

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Author Spotlight: Comprehensive Epigenetic Analysis for Investigating Human Cellular Plasticity and Environmental Adaptation Using Immunofluorescence Assays

Published on: June 28, 2024

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Substructure Analyzer: A User-Friendly Workflow for Rapid Exploration and Accurate Analysis of Cellular Bodies in Fluorescence Microscopy Images

Published on: July 15, 2020

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

A Cell-Free Assay Using Xenopus laevis Embryo Extracts to Study Mechanisms of Nuclear Size Regulation

Published on: August 8, 2016

Area of Science:

Cell Biology
Molecular Biology
Biochemistry

Background:

Nuclear bodies are known to accelerate reactions within confined cellular spaces.
The specific function of the histone locus body in gene expression regulation has been largely unknown.

Purpose of the Study:

To provide direct evidence for the functional role of the histone locus body.
To investigate the mechanism by which the histone locus body contributes to histone pre-mRNA processing.

Main Methods:

The study utilized advanced microscopy and biochemical assays to visualize and analyze the composition of the histone locus body.
Researchers focused on identifying and quantifying key factors involved in histone pre-mRNA processing within this nuclear compartment.

Main Results:

Direct evidence demonstrates that the histone locus body concentrates essential factors required for histone pre-mRNA processing.
This concentration mechanism is shown to be critical for efficient and accurate processing of histone pre-mRNAs.

Conclusions:

The histone locus body functions as a specialized compartment that enhances the efficiency of histone pre-mRNA processing.
This finding reveals a novel regulatory mechanism for gene expression involving nuclear body organization.