Related Experiment Video
Updated: Mar 20, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
Circadian Control of Antibacterial Immunity: Findings from Animal Models
Landry L Tsoumtsa1, Cedric Torre1, Eric Ghigo1
1Centre National de la Recherche Scientifique UMR 7278, IRD198, Institut National de la Santé et de la Recherche Médicale U1095, Institut Hospitalier Universitaire Méditerranée-Infection, Aix-Marseille Université Marseille, France.
Abstract:
Most of the biological functions, including the immune system, are linked to circadian rhythms in living organisms. Changes occurring to biological parameters as the result of these circadian rhythms can therefore affect the outcome of a disease. For decades, model organisms have proven to be a great tool to understanding biological mechanisms such as circadian cycle and immunity. In this review, we created an inventory of the use of model organisms in order to decipher the relation between circadian rhythms and antibacterial immunity.
Related Concept Videos
Circadian Rhythms and Gene Regulation
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Clinical Significance of Antibiotic Resistance
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

