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A non-contact approach for PWV detection: application in a clinical setting
Adriaan Campo1, Hilde Heuten, Inge Goovaerts
1Laboratory of Biomedical Physics, Faculty of Science, University of Antwerp, Groenenborgerlaan 171 B-2020 Antwerp, Belgium. Ultrasound Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, 630 West 168th Street, NY 10032, USA.
Physiological Measurement
|June 1, 2016
Summary
Laser Doppler vibrometry (LDV) offers a new, non-invasive method to measure local pulse wave velocity (PWV) in the common carotid artery (CCA). This technique shows potential as a valid marker for arterial stiffness and health.
Area of Science:
- Cardiovascular diagnostics
- Biomedical engineering
- Arterial stiffness assessment
Background:
- Arteriosclerosis screening necessitates reliable methods for measuring pulse wave velocity (PWV), an indicator of arterial stiffness.
- Carotid-femoral PWV (cfPWV) is a standard but has limitations; local common carotid artery (CCA) stiffness measurement is an alternative.
- Laser Doppler vibrometry (LDV) presents a novel approach for local PWV assessment.
Purpose of the Study:
- To evaluate the validity and feasibility of using laser Doppler vibrometry (LDV) for local pulse wave velocity measurement in the common carotid artery (CCA).
- To assess the correlation of LDV-measured PWV (PWVLDV) with established cardiovascular risk factors and arterial stiffness parameters.
Main Methods:
- A pilot study involving 48 patients (aged 48-70) with known atherosclerotic disease (CAD, CVD, PAD).
- Measurement of local PWV in the CCA using laser Doppler vibrometry (PWVLDV).
- Concurrent evaluation of carotid-femoral PWV (cfPWV), CCA distensibility coefficient (DC), CCA intima-media thickness (IMT), blood pressure (BP), and age.
Main Results:
- Laser Doppler vibrometry (LDV) proved to be a valid method for local PWV measurement in the CCA (PWVLDV).
- PWVLDV showed a significant correlation with age (R=0.432; p=0.002), consistent with other techniques.
- Measured PWVLDV values ranged from 2.5 to 5.8 m/s, aligning with existing literature for local CCA PWV.
Conclusions:
- PWVLDV measured by laser Doppler vibrometry is a potentially valuable, non-invasive marker for assessing arterial health.
- The method is user-friendly and causes no patient discomfort, suggesting clinical applicability.
- Further research with larger, homogeneous populations and integration of blood velocity measurements and reference methods (PWI, MRI) is recommended.
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