[EXPERIENCE OF THE RATIONAL ANTIBACTERIAL THERAPY CONDUCTION IN TREATMENT OF CHILDREN FOR THE BURN TRAUMA]

Area of Science:

• Pediatric Burn Care
• Infectious Disease Management
• Pharmacology

Context:

• Analysis of 808 pediatric burn trauma cases treated in a specialized hospital.
• Antibacterial therapy was administered to 40.3% of patients.
• Empirical antibiotic selection considered departmental bacteriology and patient premorbidity.

Purpose:

• To analyze the principles of rational antibacterial therapy in pediatric burn trauma.
• To evaluate the efficacy of probiotics in preventing antibiotic-associated diarrhea.
• To identify effective strategies for managing complications of antibacterial therapy in pediatric burn patients.

Summary:

• 808 pediatric burn trauma patients were studied, with 40.3% receiving antibacterial therapy.
• Antibiotics were prescribed empirically, often as monotherapy (82.2%).
• Co-administration of anticlostridial probiotics (Lactobacillus rhamnosus R0011, Lactobacillus acedofilus R0052) with antibiotics effectively prevented antibiotic-associated diarrhea.

Impact:

• Highlights the importance of rational antibiotic use in pediatric burn patients.
• Demonstrates the prophylactic role of specific probiotics against a frequent complication.
• Provides evidence-based recommendations for improving treatment outcomes in pediatric burn care.