[COMPARATIVE CHARACTERISTIC OF VARIOUS METHODS OF SIMULATION OF BILIARY PERITONITIS IN EXPERIMENT].

Area of Science:

• Veterinary Medicine
• Surgical Research
• Infectious Disease Modeling

Background:

• Biliary peritonitis is a serious complication following gallbladder procedures.
• Accurate simulation models are essential for research into treatment strategies.

Purpose of the Study:

• To compare the efficacy of different methods for simulating biliary peritonitis in a rabbit model.
• To identify the most reliable method for inducing diffuse biliary peritonitis.

Main Methods:

• Gallbladder perforation was performed in 6 rabbits.
• Intra-abdominal injection of sterile bile (5-40 ml) was administered to 7 rabbits.
• A combination of intra-abdominal sterile bile injection and E. coli culture was used in 23 rabbits.

Main Results:

• Gallbladder perforation resulted in local serous-fibrinous peritonitis in 50% of cases.
• Bile injection alone failed to induce diffuse peritonitis with exudates or fibrin.
• The combined bile and E. coli method induced diffuse biliary peritonitis in all animals (76% serous-fibrinous, 24% purulent-fibrinous).

Conclusions:

• Intra-abdominal injection of sterile bile combined with E. coli is the most effective method for simulating diffuse biliary peritonitis in rabbits.
• This model provides a reliable platform for investigating therapeutic interventions for biliary peritonitis.