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Updated: Mar 20, 2026
Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7)
1Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA, 94720, USA.
Abstract:
Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic stem cell aging. In this chapter, we provide a methodology to characterize the molecular, cellular, and physiological functions of SIRT7.
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