Related Experiment Video
Updated: Mar 20, 2026
Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel
Published on: January 11, 2012
Neuronal commitment of human circulating multipotent cells by carbon nanotube-polymer scaffolds and biomimetic
Giorgia Scapin1, Thomas Bertalot2, Nicola Vicentini3
1Department of Biology, University of Padua, 35131 Padua, Italy.
Aim:
We aimed to set up a self-standing, biomimetic scaffold system able to induce and support per se neuronal differentiation of autologous multipotent cells.
Materials & Methods:
We isolated a population of human circulating multipotent cells (hCMCs), and used carbon nanotube/polymer nanocomposite scaffolds to mimic electrical/nanotopographical features of the neural environment, and biomimetic peptides reproducing axon guidance cues from neural proteins.
Results:
hCMCs showed high degree of stemness and multidifferentiative potential; stimuli from the scaffolds and biomimetic peptides could induce and boost hCMC differentiation toward neuronal lineage despite the absence of exogenously added, specific growth factors.
Conclusion:
This work suggests the scaffold-peptides system combined with autologous hCMCs as a functional biomimetic, self-standing prototype for neural regenerative medicine applications.
More Related Videos
07:50Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
Published on: June 2, 2020
10:45Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017