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Effect of diethylnitrosamine on monoamine oxidase in rat liver
T Obata1, H Yamashita, T Egashira
1Department of Pharmacology, Medical College of Oita, Japan.
Japanese Journal of Pharmacology
|January 1, 1989
Abstract:
The effect of diethylnitrosamine (DEN), a well-known experimental carcinogen, toward MAO-A and MAO-B activity of rat liver was investigated. The oxidations of both beta-PEA (MAO-B) and 5-HT (MAO-A) were inhibited by DEN. The K1 values of DEN in the inhibition of rat liver MAO-A and MAO-B activity were determined. The kinetic data show that DEN is a competitive, MAO-B selective inhibitor and its inhibitory effect on MAO-B is about 4-fold more potent than that on MAO-A. DEN might change the proportions of the multiple forms of MAO activity in tumor cells.