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Obstructive Fibrinous Tracheal Pseudomembrane After Endotracheal Intubation
Inderpaul Singh Sehgal1, Sahajal Dhooria1, Amanjit Bal2
1Department of Pulmonary Medicine.
Abstract:
Obstructive fibrinous tracheal pseudomembrane (OFTP) is an uncommon complication that results after tracheal intubation. Herein, we perform a systematic review of the PubMed and EmBase databases for all the cases describing OFTP. The systematic search yielded 28 citations describing 53 subjects with OFTP. The study population (61.1% females) comprised of both adults and pediatric subjects with a median (IQR) age of 40.5 (14.8-60.5) years. The median (IQR) size of endotracheal tube was 7.5 (6-9.3) mm with a median (IQR) duration of intubation of 36 (14-96) hours. The median (IQR) time to onset of symptoms after extubation was 24 (6-96) hours. Stridor was the most common symptom. The average delay in correctly identifying the OFTP was 26 hours. The diagnosis of tracheal pseudomembrane was confirmed by flexible bronchoscopy in 38 (70.4%) instances while rigid bronchoscopy was used in 46.3% subjects for removing the pseudomembrane. There were two deaths, one each in an adult and a pediatric subject. OFTP is a complication of tracheal intubation and presents with respiratory failure. The diagnosis can be confirmed by flexible bronchoscopy. Treatment involves removal of the obstructing membrane with either flexible or rigid bronchoscopy.
Insights
Obstructive fibrinous tracheal pseudomembrane (OFTP) is a rare complication after tracheal intubation. Diagnosis is confirmed via flexible bronchoscopy, and treatment involves membrane removal using bronchoscopy.
Area of Science:
- Pulmonology
- Critical Care Medicine
Background:
- Obstructive fibrinous tracheal pseudomembrane (OFTP) is an uncommon complication following tracheal intubation.
- It can lead to significant respiratory distress and failure.
Purpose of the Study:
- To systematically review all reported cases of OFTP.
- To analyze patient demographics, intubation parameters, clinical presentation, diagnosis, and treatment outcomes.
Main Methods:
- Systematic review of PubMed and EmBase databases.
- Inclusion of all case reports describing OFTP.
- Data extraction on patient characteristics, intubation details, and management.
Main Results:
- Reviewed 28 citations describing 53 subjects with OFTP.
- Median age was 40.5 years; 61.1% were female.
- Common symptoms included stridor; diagnosis confirmed by flexible bronchoscopy (70.4%); treatment via flexible or rigid bronchoscopy.
Conclusions:
- OFTP is a serious complication of tracheal intubation requiring prompt diagnosis and intervention.
- Flexible bronchoscopy is effective for both diagnosis and treatment of OFTP.
- While rare, OFTP can have fatal outcomes.
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