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Updated: Mar 20, 2026

Postproduction Processing of Electrospun Fibres for Tissue Engineering

Postproduction Processing of Electrospun Fibres for Tissue Engineering

Published on: August 9, 2012

Sterilization techniques for biodegradable scaffolds in tissue engineering applications.

Zheng Dai¹, Jennifer Ronholm², Yiping Tian¹

¹Department of Chemical and Biological Engineering, University of Ottawa, Ottawa, ON, Canada.

Journal of Tissue Engineering

|June 2, 2016

Summary

Sterilizing biodegradable scaffolds is crucial for preventing infections in tissue engineering. This review compares heat, chemical, irradiation, and novel methods for effective scaffold sterilization.

Keywords:

Biodegradable scaffolds biomaterials sterilization tissue engineering

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Area of Science:

Biomaterials Science
Tissue Engineering
Microbiology

Background:

Biodegradable scaffolds are vital in biomaterials and tissue engineering.
Infections from microbiological contaminants pose a significant challenge during in vivo scaffold use.

Purpose of the Study:

To review and compare various sterilization techniques for biodegradable scaffolds.
To analyze the mechanisms, effects, and efficiencies of different sterilization methods.

Main Methods:

Literature review of sterilization techniques.
Analysis of heat, chemical, irradiation, and novel sterilization methods.
Comparison of sterilization mechanisms, post-sterilization effects, and efficiencies.

Main Results:

Different sterilization techniques exhibit varying efficiencies and impacts on scaffold properties.
Selection of sterilization method depends on scaffold material and intended application.
Novel techniques show promise for improved biocompatibility and efficacy.

Conclusions:

Effective sterilization is critical for the safe application of biodegradable scaffolds.
A comprehensive understanding of sterilization methods is needed to mitigate infection risks.
Further research into advanced sterilization techniques is warranted for tissue engineering.