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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Autonomic and peripheral nervous system function in acute tick-borne encephalitis
Bernhard Neumann1, Wilhelm Schulte-Mattler1, Sophie Brix1
1Department of Neurology University Medical Centre Regensburg Regensburg Germany.
Brain and Behavior
|June 2, 2016
Summary
Acute tick-borne encephalitis (TBE) affects the autonomic nervous system (ANS) and peripheral nervous system (PNS). TBE patients show signs of sympathovagal imbalance and reduced nerve function, similar to diabetic polyneuropathy.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Tick-borne encephalitis (TBE) is a growing flaviviral zoonosis in Europe.
- TBE can manifest as meningitis, meningoencephalitis, or meningoencephalomyelitis.
- Autonomic (ANS) and peripheral nervous system (PNS) dysfunction may cause acute and long-term TBE complications.
Purpose of the Study:
- To investigate ANS and PNS involvement in acute TBE.
- To compare TBE neurological effects with diabetic polyneuropathy (d-PNP) and healthy controls (HC).
Main Methods:
- Prospective study of 14 acute TBE patients, 17 d-PNP patients, and 30 HC.
- Assessed ANS/PNS function via heart rate variability (HRV) and sural/tibial nerve neurography.
- Primary endpoint: HRV at rest (RMSSD). Autonomic symptoms and quality of life (QoL) were surveyed.
Main Results:
- TBE patients exhibited significantly lower resting HRV (RMSSD) and increased sympathetic activity (LF/HF ratio), similar to d-PNP.
- Reduced nerve conduction velocities and action potential amplitudes were observed in TBE patients compared to HC.
- TBE patients reported more autonomic symptoms and lower QoL.
Conclusions:
- Acute TBE impacts both the ANS and, to a lesser extent, the PNS.
- This neurological involvement may contribute to TBE's short- and long-term morbidity.
Keywords:
Autonomic nervous systemcentral nervous system infectionencephalitisinflammatory neuropathymeningitisMore Related Videos
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