IRAK1 variant is protective for orthodontic-induced external apical root resorption

Area of Science:

• Genetics
• Orthodontics
• Molecular Biology

Background:

• The Interleukin-1 beta (IL1B) pathway is implicated in orthodontic-induced external apical root resorption (EARR).
• Identifying genetic factors influencing EARR is crucial for developing predictive models.
• Understanding the genetic basis of EARR can inform treatment strategies and patient management.

Purpose of the Study:

• To identify genes within the IL1 pathway associated with EARR.
• To explore the potential of these genes as candidate markers for EARR.
• To contribute to an integrative predictive model for EARR.

Main Methods:

• A stepwise multiple linear regression model was employed.
• 195 patients undergoing orthodontic treatment were analyzed.
• Genotyping of three single nucleotide polymorphisms (SNPs) was performed: IL1B (rs1143634), IL1RN (rs315952), and IRAK1 (rs1059703).

Main Results:

• The predictive model included four clinical variables and one SNP, explaining 30% of EARR variability.
• Significant predictors of EARR included gender, treatment duration, premolar extractions, and Hyrax appliance use.
• Homozygosity/hemizygosity for the IRAK1 gene variant C (rs1059703) was identified as a protective factor against EARR.

Conclusions:

• IRAK1 polymorphism is a potential protective variant for EARR.
• This genetic marker could be incorporated into predictive models for EARR.
• Further research is warranted to validate IRAK1's role in EARR and its clinical implications.