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Related Concept Videos

Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing...
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Desmosomes01:05

Desmosomes

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The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
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Assessment of the Cardiovascular System II: Inspection01:29

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Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
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Related Experiment Video

Updated: Mar 20, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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[DRESS syndrome].

Monika Adamcová, Igor Šturdík, Tomáš Koller

    Vnitrni Lekarstvi
    |June 3, 2016
    PubMed
    Summary

    Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) is a severe drug reaction. Early diagnosis and consideration of allopurinol are crucial for managing this potentially fatal condition.

    Area of Science:

    • Clinical immunology
    • Dermatology
    • Pharmacology

    Background:

    • Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) is a severe, idiosyncratic drug reaction.
    • It typically manifests days to weeks after drug initiation in susceptible individuals.
    • Key features include organ damage, eosinophilia, and characteristic skin rash.

    Observation:

    • A case report details a 56-year-old female presenting with fever, elevated liver enzymes, and a skin rash.
    • The patient's clinical presentation was consistent with DRESS syndrome.
    • Allopurinol was identified as the causative agent responsible for the reaction.

    Findings:

    • DRESS syndrome diagnosis was confirmed in the presented case.
    • Allopurinol was identified as the specific drug triggering the DRESS syndrome.

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  • The patient's symptoms included fever, elevated liver tests, and skin rash, typical of DRESS.
  • Implications:

    • DRESS syndrome requires prompt recognition due to its potential for severe morbidity and mortality.
    • Allopurinol should be considered a potential culprit in patients presenting with DRESS-like symptoms.
    • Clinicians should include DRESS syndrome in the differential diagnosis for patients with unexplained fever, rash, and organ involvement.